生物工程系-孙虎男

发布者:韦人月发布时间:2019-11-15浏览次数:1724

孙 虎 男 个 人 简 介



孙虎男197801月,博士研究生兽医学博士,博士后,副教授、硕导。

研究方向:抗癌新药研发;靶向肿瘤干细胞的抗癌策略研究;低温等离子体生物学效应

教学工作:

本科生课程:细胞生物学;细胞生物学实验

研究生课程:细胞信号传导;动物组织细胞培养

育经历:

2005.03-2008.08韩国忠南大学校兽医大学兽医机能学博 士

2003.03-2005.02韩国忠南大学校自然大学细胞分子生物学硕 士

1996.09-2000.06延边大学农学院动物医学专业学 士

工作经历:

2020.09-至今  黑龙江八一农垦老员工命科学技术学院生物工程系副教授

2019.01-2019.06韩国济州老员工命资源科学学院干细胞实验室研究教授

2012.03-2016.06黑龙江八一农垦老员工命科学技术学院生物工程系系主任

2010.09-2020.08黑龙江八一农垦老员工命科学技术学院生物工程系讲师

2008.09-2010.09韩国生命工学研究院 细胞治疗研究室        博士后

2002.12-2008.08韩国生命工学研究院 疾病模式动物研究中心研究员

2000.07-2002.12延边大学农学院 农学系辅导员

科研教研项目:

  1. 黑龙江省自然科学基金联合培育项目博来霉素诱导肺纤维化过程中Prx I的调控作用机制,2022.09-2025.0910万,在研,主持人

  2. beat365体育官网平台“三纵三横”科研资助项目,靶向线粒体自噬性凋亡的低温等离子体技术抗癌机制研究,2020.08.31-2023.08.311.5万,在研,主持人

  3. 黑龙江省自然科学基金面上项目C2015036, Prx I LPS诱导小鼠死亡的保护作用及其机理研究,2015.07.-2018.07.6万,已结题,主持人

  4. beat365体育官网平台校内培育课题(重点)XA2014-04, Prx I对巨噬细胞TLR4信号通路的调控及其机制研究,2014-10-2017.10, 5万,已结题,主持人

  5. 黑龙江省博士后科研启动项目LBH-Q11024, 新活性氧抑制剂对小胶质细胞清除淀粉样沉淀的作用及机理研究,2011.12-2014.12, 5万,已结题,主持人。

  6. beat365体育官网平台学成引进人才科研启动项目XYB2011-14,神经小胶质细胞活性抑制剂的筛选研究,2011.9-2014.9, 5万,已结题,主持人。

  7. 黑龙江省教育厅海外学人科研资助项目1251H010,神经小胶质细胞活性氧抑制剂的研究与开发,2011.6-2014.65万,已结题,主持人。

  8. 国家教育部留学人员科研启动资金项目,教外司留【2013693号,新甾体酮肟化合物对LPS 诱导的巨噬细胞体外吞噬和NO 分泌的抑制作用及其机理研究2013.9-2016.93万,已结题,主持人。

  9. 国家自然基金面上项目31172353,羊传染性脓疱病毒保护性抗原表位筛选及表位作图研究,2012.01-2015.1250万,已结题,第四参加人。

  10. 国家自然基金青年项目31101799,牛干扰素-g 诱导牛原代培养肝细胞凋亡通路的研究,2012.01-2014.1223万,已结题,第二参加人。

代表论文:

一、期刊论文

1. 第一作者论文

  1. Hu-Nan Sun, Chen-Xi Ren, Dong Hun Lee, Wei-Hao Wang, Xiao-Yu Guo, Ying-Ying Hao, Xiao-Ming Wang, Hui-Na Zhang, Wan-Qiu Xiao, Nan Li, Jie Cong, Ying-Hao Han and Taeho Kwon. PRDX1 Negatively Regulates Bleomycin-Diduced Pulmonary Fibrosis via Inhibiting the Epithelial-Mesenchymal Transition and Lung Fibroblast Proliferation in vitro and in vivo. Cellular & Molecular Biology Letters 2023(28):48 (IF=8.712, 1区, Top) .

  2. Sun HN, Guo XY, Xie DP, Wang XM, Ren CX, Han YH, Yu NN, Huang YL, Kwon T. Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells. Aging (Albany NY) 2022 May 11;14(9):4000-4013. (IF=5.9552)

  3. Sun HN, Xie DP, Ren CX, Guo XY, Zhang HN, Xiao WQ, Han YH, Cui YD, Kwon T. Ethyl β-Carboline-3-Carboxylate Increases Cervical Cancer Cell Apoptosis Through ROS-p38 MAPK Signaling Pathway. In Vivo  2022 May-Jun;36(3):1178-1187. (IF=2.44)  

  4. HU-NAN SUN, CHEN-XI REN, YI-XI GONG1, DAN-PING XIE and TAEHO KWON. Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung cancer development. Oncology Letter 2021 Jun;21(6):465.(IF=2.34) Review

  5. Chandimali N, Sun HN(co-first), Park YH, Kwon T. BRM270 Suppresses Cervical Cancer Stem Cell Characteristics and Progression by Inhibiting SOX2. In Vivo. 2020 May-Jun;34(3):1085-1094. IF=1.64区)

  6. Koh H, Sun HN (co-first), Xing Z, Liu R, Chandimali N, Kwon T, Lee DS. Wogonin Influences Osteosarcoma Stem Cell Stemness Through ROS-dependent Signaling. In Vivo. 2020 May-Jun;34(3):1077-1084. IF=1.64区)

  7. Zhen X, Sun HN(co-first), Liu R, Choi HS, Lee DS. Non-thermal plasma-activated Medium Induces Apoptosis of Aspc1 Cells Through the ROS-dependent Autophagy Pathway.In Vivo.2020 Jan-Feb;34(1):143-153. IF=1.64

  8. Chandimali N, Sun HN(co-first), Kong LZ, Zhen X, Liu R, Kwon T, Lee DS. Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression.Anticancer Res.2019 Nov;39(11):6115-6123. (IF=1.84)

  9. Jin YZ, Sun HN(co-first), Liu Y, Lee DH, Kim JS, Kim SU, Jiao BY, Han YH, Jin MH, Shen GN, Lee DS, Kwon T, Xu DY, Jin YU. Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway. In Vivo. 2019 Jul-Aug;33(4):1183-1192. IF=1.64

  10. Sun HN, Liu Y, Wang JN, Wang C, Liu R, Kong LZ, Zhen X, Chandimali N, Cui YD, Kim SU, Lee DS, Yu DY, Kim JS, Jeong DK, Kwon T, Han YH. Protective Role of Peroxiredoxin I in Heat-Killed Staphylococcus Aureus-infected Mice. In Vivo. 2019 May-Jun;33(3):749-755IF=1.64

  11. Sun HN, Luo YH, Meng LQ, Piao XJ, Wang Y, Wang JR, Wang H, Zhang Y, Li JQ, Xu WT, Liu Y, Zhang Y, Zhang T, Han YH, Jin MH, Shen GN, Zang YQ, Cao LK, Zhang DJ, Jin CH.  Cryptotanshinone induces reactive oxygen speciesmediated apoptosis in human rheumatoid arthritis fibroblastlike synoviocytes.Int J Mol Med. 2019 Feb;43(2):1067-1075. (IF=2.783)

  12. Hu-Nan Sun, Li Feng, Ai-Guo Wang, Jing-Yu Wang, Lei Liu, Mei-Hua Jin, Gui-Nan Shen, Cheng-Hao Jin, Dong-Soek Lee, Tea-Ho Kwon, Yu-Dong Cui, Dae-Yeul Yu & Ying-Hao Han. Peroxiredoxin I deficiency increases LPS-induced lethal shock in mice.Mol Med Rep. 2018(IF=1.9224)

  13. Liu C, Sun HNco-first, Luo YH, Piao XJ, Wu DD, Meng LQ, Wang Y, Zhang Y, Wang JR, Wang H, Xu WT, Li JQ, Liu Y, Wu YQ, Han YH, Shen GN, Jin MH, Zang YQ, Li JC, Fang NZ, Cui YD, Jin CH. Cryptotanshinone induces ROS-mediated apoptosis in human gastric cancer cells.Oncotarget. 2017 Dec 15;8(70): (IF=5.0)

  14. Sun HN, Han YH, Feng L, Jin CH, Han B, Liu L, Lee DS, Kwon TH, Li LG, Ge WZ, Cui YD. 16α, 17α-epoxypregnenolone-20-oxime inhibits NO and IL-6 production in LPS-treated RAW264.7 cells. Mol Med Rep. 2016 Jun;13(6):4927-33 (IF=1.9224)

  15. Sun HN, Shen GN, Jin YZ, Jin Y, Han YH, Feng L, Liu L, Jin MH, Luo YH, Kwon TH, Cui YD, Jin CH. 2-cyclohexylamino-5,8-dimethoxy-1,4-naphthoquinone inhibits LPS-induced BV2 microglial activation through MAPK/NF-kB signaling pathways.Heliyon.2016Jul 20;2(7)

  16. Sun HN, Jin MH, Han B, Feng L, Han YH, Shen GN, Yu YZ, Jin CH, Lian ZX, Lee DS, Kim SU, Ge WZ, Cui YD. 16α,17α-Epoxypregnenolone-20-oxime prevent LPS-induced NO production and iNOS expression in BV-2 microglial cells by inhibiting JNK phosphorylation. Biol Pharm Bull. 2014;37(7):1096-102. (IF=1.6944)

  17. Sun HN, Kim SU, Huang SM, Kim JM, Park YH, Kim SH, Yang HY, Chung KJ, Lee TH, Choi HS, Min JS, Park MK, Kim SK, Lee SR, Chang KT, Lee SH, Yu DY, Lee DS. Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades.J Neurochem. 2010 Jul;114(1):39-50. (IF=4.62)

  18. Sun HN, Kim SU, Lee MS, Kim SK, Kim JM, Yim M, Yu DY, Lee DS. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of phosphoinositide 3-kinase and p38 mitogen-activated protein kinase signal pathways is required for lipopolysaccharide-induced microglial phagocytosis.Biol Pharm Bull. 2008Sep;31(9):1711-5. (IF=1.6944)

  1. 通讯作者论文(与第一作者论文无重复)

  1. Han YH, Feng L, Lee SJ, Zhang YQ, Wang AG, Jin MH, Sun HN*(co-correspondence), Kwon T*. Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis. Cell Death Discov. 2023 Jul 27;9(1):263 (IF=7.109, 2区)

  2. Weihao Wang, Fang Kou, Juan Wang, Zhigang Quan, Shuting Zhao, Yifei Wang, Xin Hu, Hunan Sun*(co-correspondence) and Longkui Cao*. Pretreatment with millet-derived selenylated soluble dietary fiber ameliorates dextran sulfate sodium-induced colitis in mice by regulating inflammation and maintaining gut microbiota balance. Front. Nutr., 07 September 2022. doi.org/10.3389/fnut.2022.928601(IF=6.591)

  3. Xie DP, Gong YX, Lee J, Jeong EM, Ren CX, Guo XY, Han YH, Cui YD, Lee SJ, Kwon T, Sun HN*. Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathways. J Cancer2022 Sep 6;13(11):3258-3267. (IF=4.473)

  4. ChenXi Ren1†, Xin Jin2†, DanPing Xie1 , XiaoYu Guo1 , LiYun Yu1 , YuDong Cui1*, Taeho Kwon3* and HuNan Sun1,* Hispidin attenuates bleomycin-induced idiopathic pulmonary fbrosis via an anti-oxidative efect in A549 cells. Appl Biol Chem (2021) 64:74 (IF=3.2064)

  5. Jin MH, Chen DQ, Jin YH, Han YH, Sun HN(co-correspondence), Kwon T. Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling. Exp Ther Med. 2021 Sep;22(3):970. (IF=2.7514)

  6. Lee J, Gong YX, Xie DP, Jeong H, Seo H, Kim J, Park YH, Sun HN(co-correspondence), Kwon T. Anticancer Effect of ERM210 on Liver Cancer Cells Through ROS/Mitochondria-dependent Apoptosis Signaling Pathways. In Vivo. 2021 Sep-Oct;35(5):2599-2608. IF=2.1554

  7. Liang WF, Gong YX, Li HF, Sun FL, Li WL, Chen DQ, Xie DP, Ren CX, Guo XY, Wang ZY, Kwon T, Sun HN. Curcumin Activates ROS Signaling to Promote Pyroptosis in Hepatocellular Carcinoma HepG2 Cells.In Vivo. 2021 Jan-Feb;35(1):249-257. IF=2.1554

  8. Chandimali N, Koh H, Kim J, Lee J, Park YH, Sun HN (co-correspondence), Kwon T. BRM270 targets cancer stem cells and augments chemo-sensitivity in cancer.Oncol Lett. 2020 Oct;20(4):103 (IF=2.34)

  9. Han YH, Zhang YQ, Jin MH, Jin YH, Qiu MY, Li WL, He C, Yu LY, Hyun JW, Lee J, Yoon DY, Sun HN (co-correspondence), Kwon T.Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway. Biochem Biophys Res Commun. 2020 Aug 27;529(3):635-641.IF=3.3223区)

  10. Han YH, Li WL, Jin MH, Jin YH, Zhang YQ, Kong LZ, Yu LY, Hyun JW, Kwon J, Sun HN (co-correspondence), Kwon T.Peroxiredoxin II Inhibits Alcohol-induced Apoptosis in L02 Hepatocytes Through AKT/β-Catenin Signaling Pathway. Anticancer Res. 2020Aug;40(8):4491-4504(IF=1.84)

  11. Gong YX, Liu Y, Jin YH, Jin MH, Han YH, Li J, Shen GN, Xie DP, Ren CX, Yu LY, Lee DS, Kim JS, Jo YJ, Kwon J, Lee J, Park YH, Kwon T, Cui YD, Sun HN*Picrasma quassioides Extract Elevates the Cervical Cancer Cell Apoptosis Through ROS-Mitochondrial Axis Activated p38 MAPK Signaling Pathway. In Vivo.2020 Jul-Aug;34(4):1823-1833IF=1.64区)

  12. Xie DP, Gong YX, Jin YH, Ren CX, Liu Y, Han YH, Jin MH, Zhu D, Pan QZ, Yu LY, Lee DS, Lee J, Kim J, Park YH, Hyun JW, Kwon T, Cui YD, Sun HN*.Anti-tumor Properties of Picrasma quassioides Extracts in H-Ras G12V Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction.Anticancer Res. 2020 Jul;40(7):3819-3830(IF=1.84)

  13. Han YH, Jin MH, Jin YH, Yu NN, Liu J, Zhang YQ, Cui YD, Wang AG, Lee DS, Kim SU, Kim JS, Kwon T, Sun HN*. Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling. In Vivo. 2020 Jan-Feb;34(1):133-141. (IF=1.64)

  14. YingHao Han†, DongQin Chen†, MeiHua Jin†, YingHua Jin , Jing Li, GuiNan Shen , WeiLong Li, YiXi Gong, YingYing Mao, DanPing Xie, DongSeok Lee, LiYun Yu, SunUk Kim, JiSu Kim ,Taeho Kwon* , YuDong Cui*and HuNan Sun* Anti-infammatory efect of hispidin on LPS induced macrophage infammation through MAPK and JAK1/STAT3 signaling pathways.Appl Biol Chem (2020) 63:21 (IF=1.64)

  15. GuiNan Shen, Lei Liu, Li Feng, Yu Jin, MeiHua Jin, YingHao Han, ChengHao Jin, YongZhe Jin, DongSoek Lee, Tae Ho Kwon, YuDong Cui &  HuNan Sun*. Knockdown of Peroxiredoxin V incrases glutamate-induced apoptosis in HT22 hippocampal neuron cells. Mol Med Rep. 2018 Jun;17(6):7827-7834. (IF=1.9224)

  16. Liu YKwon TKim JSChandimali NJin YHGong YXXie DPHan YHJin MHShen GNJeong DKLee DSCui YD and Sun HN*. Peroxiredoxin V Reduces β-Lapachone-induced Apoptosis of Colon Cancer Cells. Anticancer Res. 2019 Jul;39(7):3677-3686.(IF=1.84)

  17. Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN(co-correspondence), Lee DS, Kwon T. Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease. Int J Mol Sci. 2019 Jun 2;20(11).(IF=4.183)

  18. 肖婉秋,张惠娜,任晨曦,郭晓宇,李楠,丛杰,冯耀元,孙虎男(*过量表达peroixredoxin V 抑制苦木提取物诱导的宫颈癌SiHa细胞凋亡,中国细胞生物学学报,2023,4501):35-43

  19. 王健楠(#) ,阮洪生,崔玉东,孙虎男(*),身痛逐瘀汤通过调控P38MAPK信号通路抑制LPS诱导的RAW264.7巨噬细胞一氧化氮的分泌,beat365体育官网平台学报2015,(03):75-78

  20. 刘磊(#),申贵男,冯丽,韩英浩,罗英花,金颖华,金成浩,崔玉东,孙虎男(*)2-环戊氨基-5,8-二甲氧基-1,4-萘醌抑制LPS诱导的RAW264.7细胞内ROS水平与NO的分泌,中国细胞生物学学报2015,(04):514-521

  21. 冯丽(#) ,金永哲,刘磊,韩冰,吕春阳,崔玉东,孙虎男(*)PeroxiredoxinV保护HT22小鼠海马神经细胞抵抗NO诱导的细胞凋亡,中国细胞生物学学报,2014,(01):53-58

  22. 刘悦,焦冰洋,于楠楠,王闯,韩英浩,金成浩,孙虎男(*)β-拉帕醌通过下调过氧化物酶V诱导SW480结肠癌细胞凋亡,中国细胞生物学学报2016.12.15,(12):1487~1493

  23. 王闯,孙虎男,金成浩(*Prdx V在链脲佐菌霉素诱导MIN6细胞凋亡过程中的调控作用,中国细胞生物学学报2018,402):202-209



科研教研奖励:

  • 黑龙江省大庆市第二十六届自然科学技术学术成果奖(第一完成人)二等2017

  • 黑龙江省第二届高校青年教师多媒体课件制作大赛(第一完成人)三等2014

  • 第二届全国老员工生命科学创新创业大赛指导老师(第一指导老师)三等2017

  • 第三届全国老员工生命科学创新创业大赛指导老师(第一指导老师)一等2018

  • 第四届全国老员工生命科学创新创业大赛指导老师(第一指导老师)一等2019

  • 黑龙江省农垦总局科技进步奖(第一完成人)    二等  2020

专著:

  • 《过氧化物酶与细胞》, 孙虎男(第一作者) 2020.07 东北林业大学出版社,ISBN978-7-5674-2188-2